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Lipid metabolism in MASLD and MASH: From mechanism to the clinic

Year: 2024
Type: article
Abstract: lipogenesis and excess fatty acid transport to the liver (due to increased lipolysis, adipose tissue insulin resistance, as well as excess dietary fatty acid intake, in particular of saturated fatty acids). Not only triglycerides but also other lipids are secreted by the liver and are associated with a worse histological profile in MASH, as shown by lipidomics. Herein, we review the role of lipid metabolism in MASLD/MASH and discuss the impact of weight loss (diet, bariatric surgery, GLP-1RAs) or other pharmacological treatments (PPAR or THRβ agonists) on hepatic lipid metabolism, lipidomics, and the resolution of MASH.
Source: JHEP Reports
DOI: 10.1016/j.jhepr.2024.101185
Institutions: Istituto di Fisiologia Clinica, National Research Council, University of Cambridge, Wellcome/MRC Institute of Metabolic Science, Centro de Investigacion Principe Felipe, Medical Research Council
Language: English
Subfield: Epidemiology
Field: Medicine
Open Access status: gold
Estimated APC paid: $2,900
Funders: Juvenile Diabetes Research Foundation United States of America, Sophia University, Innovative Health Initiative, European Commission, Horizon 2020 Framework Programme, HORIZON EUROPE Framework Programme, Medical Research Council, H2020 Health
OpenAlex ID: W4401445004
FWCI: 37.31
Cites: 137
Cited by: 144
Related to: 10