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Preparation of Benzo[a]fluorenes via Pd-Catalyzed Annulation of 5-(2-Bromophenyl)pent-3-en-1-ynes

Year: 2024

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide A palladium-promoted cascade cyclization of 5-(2-bromophenyl)pent-3-en-1-ynes is developed for the synthesis of benzo[ a ]fluorene derivatives. The reaction proceeds with oxidative addition of C–Br, insertion, C–H activation, and reductive elimination in sequential steps.

Source: The Journal of Organic Chemistry

DOI: 10.1021/acs.joc.4c01286

Authors: Cheng-Kai Hsu, Yi-Hung Liu, Shiuh-Tzung Liu

Institution: National Taiwan University

Language: English

Topic: Catalytic C–H Functionalization Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funder: National Science and Technology Council