Work

Decreased ability to manage increases in reactive oxygen species may underlie susceptibility to arrhythmias in mice lacking Scn1b

Year: 2024

Type: article

Abstract: Using an oxidative challenge, we demonstrated that isolated cells from Scn1b−/− mice are more susceptible to cell death and surges in reactive oxygen species accumulation. At the whole organ level, they were also more susceptible to the formation of cardiac arrhythmias. This may in part be due to changes to the glutathione antioxidant system.

Source: American Journal of Physiology-Heart and Circulatory Physiology

DOI: 10.1152/ajpheart.00265.2024

Authors: Jessa L. Aldridge, Emily Davis Alexander, Allison A. Franklin, Chad R. Frasier

Institution: East Tennessee State University

Language: English

Topic: Cardiac electrophysiology and arrhythmias

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: East Tennessee State University, National Institute of Neurological Disorders and Stroke