Four new homoisoflavonoids from Caesalpinia pulcherrima
Year: 2024
Type: article
Abstract: Four new homoisoflavonoids, 7-hydroxy-3-[hydroxy(4′-methoxyphenyl)methyl]-benzopyran-4-one (1), (3R)-7, 8-dihydroxy-3-(4′-methoxybenzyl)-chroman-4-one (2), 7-hydroxy-3-(2′-hydroxy-4′-methoxybenzyl)-chroman-4-one (3), and 7-hydroxy-3-(2′-hydroxy-4′-methoxybenzyl)-benzopyran-4-one (4), were isolated from the seeds of Caesalpinia pulcherrima. The structures of new compounds were elucidated by MS and NMR spectra. Their absolute configurations were assigned using electronic circular dichroism spectrum. Compounds 2 and 4 exhibited cytotoxic effects on MCF-7/TAM cells with the IC50 values of 101.4 ± 0.03 and 93.02 ± 0.03 μM, respectively.
Authors: Yu-Cheng Zheng, Wen-Jian Gu, Ren-Geng Shu, Pu-Zhao Zhang
Institution: Jiangxi University of Traditional Chinese Medicine
Language: English
Topic: Bioactive natural compounds
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W4401457171