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Statin therapy improves locomotor muscle microvascular reactivity in patients with heart failure with preserved ejection fraction

Year: 2024
Type: article
Abstract: This was the first study to investigate the impact of statin administration on locomotor muscle microvascular function in patients with HFpEF. In support of our hypothesis, the total hyperemic response to PLM, assessed as leg blood flow area under the curve, increased, and malondialdehyde, a marker of oxidative damage, was reduced following the statin intervention. Together, these data provide new evidence for the efficacy of statin administration to improve locomotor muscle microvascular reactivity in patients with HFpEF, which may be due, in part, to reduced oxidative stress.
DOI: 10.1152/ajpheart.00427.2024
Authors: Jarred J. Iacovelli, Jeremy K. Alpenglow, Stephen M. Ratchford, Jesse C. Craig, Jonah M. Simmons, Jia Zhao, Van Reese, Kanokwan Bunsawat, Christy L. Ma, John J. Ryan, D. Walter Wray
Language: English
Field: Medicine
Open Access status: green
Awards: G139465423, G195965507, G2234508651, G2784589395, G3316947693, G5387110971, G6443578095, G6625187463, G7527160115, G8399923862, G953145429
OpenAlex ID: W4401459540
FWCI: 1.676
Cites: 26
Cited by: 4
Related to: 10