Work

Re-visiting the association between antidepressant use and the risk of lung cancer

Year: 2024

Type: article

Abstract: Observational studies suggest a potential correlation between antidepressants and increased lung cancer risks. However, existing studies are limited to small sample sizes, unadjusted covariates especially smoking status, and unclear exposure duration. We performed a large-scale retrospective cohort study to re-examine the association. We analyzed non-smokers and smokers separately to eliminate the confounding effect of smoking status. We found patients with long-term antidepressant use were at a lower risk of lung cancer in both smokers and non-smokers (odds ratio (OR), 0.61; 95% CI: 0.46-0.80, OR: 0.75; 95% CI: 0.65-0.86). None of the antidepressants was associated with an increased lung cancer risk.

Source: Journal of Psychopharmacology

DOI: 10.1177/02698811241268887

Authors: Ching-Fang Sun, Kuan-Pin Su, Anita S Kablinger

Institutions: Seattle Children's Hospital, University of Washington, Virginia Tech, China Medical University, An-Nan Hospital, China Medical University Hospital

Language: English

Topic: Cancer, Stress, Anesthesia, and Immune Response

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4401466584

FWCI: 0.272

Cites: 8

Cited by: 1

Related to: 10