Work

Ascorbate Preferentially Stimulates Gallium-67 Uptake in Glioblastoma Cells.

Year: 2022

Type: article

Abstract: ability of pharmacological ascorbate to alter gallium uptake in patient-derived glioblastoma cells with variable genetic backgrounds by co-incubating cells with Ga-67 ± pharmacological ascorbate. Surprisingly, we observed increased basal gallium uptake in the glioblastoma cells compared to normal human astrocytes. Further, pharmacological ascorbate treatment stimulated gallium uptake in glioblastoma cells while not affecting uptake in normal human astrocytes. This effect appears to be related to transient increases in transferrin receptor expression. Finally, pharmacological ascorbate treatment appears to stimulate gallium uptake in an iron metabolism-dependent manner. Further mechanistic experiments are required to evaluate the translational utility of ascorbate to impact gallium tumor imaging.

Source: PubMed

Authors: Michael S Petronek, M Li, J N Sarkaria, M K Schultz, B G Allen

Institutions: University of Iowa, Viewpoint Molecular Targeting (United States), Mayo Clinic

Language: English

Topic: Radiopharmaceutical Chemistry and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute

Award: Exploiting Redox Metabolism Using Pharmacological Ascorbate for Cancer Therapy