Year: 2024
Type: article
Abstract: The biomedical application of biodegradable polymers for addressing bone-related diseases has garnered considerable attention in recent years. Advances in material technology have expanded the repertoire of materials suitable for orthopedic implants, with nanomaterials playing a pivotal role in replicating crucial surface properties akin to natural tissues. This comprehensive review explores the evaluation of bioactive glass ceramics, shedding light on their properties and applications. The synthesis of composites through composite manufacturing has emerged as a strategy to enhance biocompatibility and biomechanical characteristics. They are addressing challenges associated with conventional implants and nanomaterials, whether in the form of functional nano coatings or nanostructured surfaces, present opportunities to refine implant techniques. Novel developments in orthopedic biomaterials, such as smart biomaterials, porous structures, and 3D implants, offer stimuli-responsive behavior to achieve desired implant shapes and characteristics. Bioactive and biodegradable porous polymer/inorganic composite materials are explored for bone tissue engineering scaffolds, aiming to promote bone formation and regeneration. As a prospective direction, the integration of stem cells into scaffolds hints at the creation of next-generation synthetic/living hybrid biomaterials, displaying high adaptability in biological settings. This review establishes a foundation for nanotechnology-driven biomaterials by elucidating fundamental design factors crucial for orthopedic implant performance and their response to cell differentiation, proliferation, and adhesion.
Source: Heliyon
Authors: Wenqing Liang, Chao Zhou, Juqin Bai, Hongwei Zhang, Hengguo Long, Bo Jiang, Jiangwei Wang, Xiaogang Huang, Hengjian Zhang, Jiayi Zhao
Institutions: Zhejiang Chinese Medical University, Zhoushan Hospital
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,100
Funders: Zhejiang Chinese Medical University, Bureau of Science and Technology of Zhoushan, 151 Talent's Projects in the Second Level of Zhejiang Province, Hebei Province Medical Science Research Key Project, Medical and Health Research Project of Zhejiang Province, Science and Technology Program of Zhejiang Province
OpenAlex ID: W4401477278