Work

A potential prospect: The novel treatment of intrapleural saline irrigation with intrapleural tyloxapol in treating thoracic empyema

Year: 2024

Type: article

Abstract: The treatment for empyema thoracis has been evolving over the years, including the usage of intrapleural fibrinolytic therapy (IPFT), for example, alteplase with intrapleural deoxyribonuclease (DNase) to enhance the drainage of pleural effusion. Here, we report two cases of thoracic empyema that were successfully treated with intrapleural saline irrigation and intrapleural tyloxapol apart from parenteral antibiotics as the pillar of the treatment. Both patients averted surgical procedure (decortication) and were discharged well. Upon follow-up, both cases showed clinical cure, biochemical recovery, and radiological improvement, indicating a good treatment outcome. This is the first reported cases on combination of saline irrigation with tyloxapol as alternative treatment for pleural infection.

Source: Respirology Case Reports

DOI: 10.1002/rcr2.70000

Authors: Mas Fazlin Mohamad Jailaini, Noor Amirah Saini, Mohd Jazman Che Rahim, Mohamed Faisal Abdul Hamid

Institutions: University Kebangsaan Malaysia Medical Centre, National University of Malaysia, Universiti Sains Malaysia, Hospital Universiti Sains Malaysia

Language: English

Topic: Pleural and Pulmonary Diseases

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,130