Work

Quadruple Negative Metastatic Melanoma With Gain of SOX-11 Expression and TERT Mutation

Year: 2024

Type: article

Abstract: Malignant melanoma is a common and aggressive skin cancer with a high incidence of metastases. Diagnosis is usually straightforward, based on a combination of histomorphology and immunohistochemistry. However, metastatic melanoma is notorious for its phenotypic diversity and loss of differentiation markers. Through recent developments in diagnostic immunohistochemistry and molecular pathology, several new markers are identified to be of use in confirming melanoma diagnosis, especially in undifferentiated and dedifferentiated cases. Here we report a challenging case of a 59-year-old male with splenic metastatic melanoma which revealed a loss of four diagnostic melanocytic markers including S100, SOX-10, HMB45, and MART-1, but a gain of SOX-11.

Source: Cureus

DOI: 10.7759/cureus.66651

Authors: Ekin Ozluk, Jennifer Lee, Eric X Wei

Institutions: Boston University, Louisiana State University, Louisiana State University in Shreveport, Louisiana State University Health Sciences Center Shreveport, University of South Alabama

Language: English

Topic: Cutaneous Melanoma Detection and Management

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4401490442

FWCI:

Cites: 15

Cited by:

Related to: 10