Copper‐Catalyzed Oxidative Intramolecular Cyclization for the Synthesis of 2‐Hydroxy‐Indolin‐3‐Ones
Year: 2024
Type: article
Abstract: The synthesis of substituted 2‐hydroxy‐indolin‐3‐ones has attracted considerable attention due to the frequent presence of the indole nucleus in numerous natural products and biologically active molecules. Herein, a direct access to 2‐hydroxy‐indolin‐3‐ones through copper‐catalyzed oxidative intramolecular cyclization of N‐(2‐acetylphenyl)picolinamide has been developed. This method exhibits good functional group tolerance, atom‐economy and avoids the pre‐functionalization of substrates.
Source: Advanced Synthesis & Catalysis
Authors: Haojie Ma, Fengyuan Zhou, Yuqi Li, Yuqi Zhang, Guosheng Huang, Xing Yang, Ji‐Jiang Wang
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
Awards: G1776357249, G8978265032
OpenAlex ID: W4401500904