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Heliox ventilation in elderly, hypertensive ICU patients improves microcirculation: A randomized controlled study

Year: 2024

Type: article

Abstract: BACKGROUND: Conventional mechanical ventilation has adverse impacts on the hemodynamics of elderly, hypertensive ICU patients. Limited studies have addressed ways to ameliorate these negative effects. This study aimed to determine whether heliox ventilation could improve the hemodynamics, especially microcirculation, of elderly, hypertensive patients undergoing mechanical ventilation. METHODS: ), lactic acid (Lac) and airway pressure were measured at 0,1,2,3 h under volume-controlled ventilation (VCV) mode throughout the study. Sublingual microcirculation parameters were additionally measured at 0 h and 3 h of ventilation treatment. RESULTS: increased (p < 0.05). Moreover, the sublingual microcirculation indexes in the experimental group improved compared with the control group (p < 0.05). CONCLUSIONS: Heliox ventilation improves blood pressure and microcirculation in elderly hypertensive patients and may resolve the limitations of traditional nitrogen‑oxygen ventilation. TRIAL REGISTRATION: This trial was registered. The Chinese trial registration number is ChiCTR2100043945. The date of registration is 6-3-2021.

Source: Journal of Critical Care

DOI: 10.1016/j.jcrc.2024.154897

Authors: Lili Zhou, Jing Lin, Mingkai Zhuang, Yue Wang, Qinyong Weng, Hui Zhang

Institutions: Fujian Medical University, Union Hospital

Language: English

Topic: Respiratory Support and Mechanisms

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,250