Investigating the cardiotoxicity of N-n-butyl haloperidol iodide: Inhibition mechanisms on hERG channels
Year: 2024
Type: article
Abstract: of 3.75 μM. The results presented in this study demonstrate the potential cardiotoxicity of F2 and underscore the significance of considering hERG channel interactions during its clinical development. This study aims to provide comprehensive insights into the interaction between F2 and hERG, which will may guid us in the safe use of F2 and in the development of new derivatives with high efficiency while low toxicity.
Source: Toxicology
Authors: Jilin Liao, Zhenyu Yang, Jinhua Yang, Hailing Lin, Bingxuan Chen, Hongbo Fu, Xiaojie Lin, Binger Lu, Fenfei Gao
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,900
Award: G1257781757
OpenAlex ID: W4401503080