Work

Synthesis of Aryl Naphthoquinones and Maleimides via Pd(II)‐Catalyzed Template‐Assisted m−C(sp2)−H Functionalization Reaction

Year: 2024

Type: article

Abstract: An efficient approach for the synthesis of substituted aryl naphthoquinones via a Pd(II)‐catalyzed template‐assisted m−C(sp2)−H bond functionalization reaction of arylmethane sulfonates have been demonstrated. The method involves usage of less expensive and abundant pharmacologically important scaffold naphthoquinone. A wide range of arylmethane sulfonates were examined and found to be compatible with the protocol. The protocol has also been further extended to the synthesis of various substituted aryl maleimide scaffolds. A plausible reaction mechanism has also been proposed to account for the selective distal m−C(sp2)−H bond functionalization reaction.

Source: Chemistry - A European Journal

DOI: 10.1002/chem.202402162

Authors: Ananya Dutta, Masilamani Jeganmohan

Institution: Indian Institute of Technology Madras

Language: English

Topic: Catalytic C–H Functionalization Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: Department of Science and Technology, Ministry of Science and Technology, India, Indian Institute of Technology Madras, Science and Engineering Research Board

Award: G7654778674