Work

Spontaneous and evoked angiotensin II sniffer cell activity in the lamina terminalis in vitro

Year: 2024

Type: article

Abstract: These studies used Chinese hamster ovary cells that were cloned to express an angiotensin receptor ( At1ra) and a calcium indicator (R-GECO) to detect the release of angiotensin from brain slices containing the lamina terminalis of rats. Some of the experiments use tissue from renin knockout rats. The results support the existence of an angiotensin system in the brain that may involve alternative synthetic pathways and is upregulated by intermittent hypoxia.

Source: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

DOI: 10.1152/ajpregu.00227.2023

Authors: George E. Farmer, J. Thomas Cunningham

Institution: University of North Texas Health Science Center

Language: English

Topic: Renin-Angiotensin System Studies

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: National Heart, Lung, and Blood Institute