Evaluation of Cytotoxicity and Genotoxicity of Chemical Material in Pm2.5 Filters From Three Monitoring Stations of the Air Quality Network of the Aburrá Valley
Year: 2024
Type: article
Abstract: The increase in air pollution and its adverse effects has raised concerns about regulatory policies and has encouraged the development of new air quality standards.Environmental toxicants can have various effects ranging from irritation to cell and tissue death; however, some genotoxic compounds produce alterations in the genetic material or its associated components, causing mutations or interfering with some repair or polymerization processes involved in chromosome segregation.The objective of this study was to evaluate the effect on the viability and genotoxic potential of PM 2.5 particulate matter obtained from filters collected from three monitoring stations of the air quality network in the Aburrá Valley, Colombia, on the CHO-K1 and Jurkat cell lines.The tests carried out revealed a reduction in cell viability and punctual damage to DNA.The results suggest that PM 2.5 material has genotoxic potential and can induce cancer development, as has been suggested in other studies.
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4401507136