Work

The Nodes of Ranvier: Mechanisms of Assembly and Maintenance

Year: 2024

Type: preprint

Abstract: Action potential propagation along myelinated axons requires clustered voltage-gated sodium and potassium channels. These channels must be restricted to nodes of Ranvier where the action potential is regenerated. Several mechanisms have evolved to facilitate and ensure the correct assembly and stabilization of these essential axonal domains. This review highlights the current understanding of the axon-intrinsic and glial-extrinsic mechanisms that control the formation and maintenance of the nodes of Ranvier in both the peripheral (PNS) and central (CNS) nervous systems.

Source: Cold Spring Harbor Perspectives in Biology

DOI: 10.1101/cshperspect.a041361

Authors: Matthew N. Rasband, Elior Peles

Institutions: Baylor College of Medicine, Weizmann Institute of Science

Language: English

Topic: Ion channel regulation and function

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: National Institute of Neurological Disorders and Stroke

Award: G500848091

OpenAlex ID: W4401511499

Cites: 134

Cited by: 5

Related to: 10