Work

Impact of breast milk on cortical pain response in newborns during the heel prick procedure: a randomized controlled trial

Year: 2024

Type: article

Study designs: Randomized Controlled Trial, Clinical Trial

Abstract: Objective To investigate the effects of breast milk on cortical pain response and behavioral response in newborns during heel-prick procedure. Study design A prospective, randomized controlled trial was conducted on healty-term newborns, undergoing heel blood sampling. Infants were randomly assigned to study group with receive orally 2 ml breast milk (n = 45) or a control group with no intervention (n = 45). A near-infrared spectroscopy device was used to monitor regional cerebral oxygen saturation (rScO2), while neonatal pain expression was assessed by Neonatal Pain, Agitation, and Sedation Scale (N-PASS). Results The N-PASS score (p = 0.001) and the crying time (p = 0.017) were significantly lower in the study group compared to the control group. Although the mean rScO2 values decreased in both groups during the procedure, the percent change in rScO2 was not significant difference between two groups. Conclusion Breast milk administration decreases behavioral responses to a noxious stimulus without reducing the cortical response to pain. Clinical trial registration This trial was registered under ClinicalTrials.gov identifier no. NCT05961904.

Source: Journal of Perinatology

DOI: 10.1038/s41372-024-02081-4

Authors: Ozgul Bulut, Seyma Cagla Topaloglu, Nurgul Bulut, Meryem Hocaoglu, Sertac Arslanoglu

Institution: Istanbul Medeniyet University

Language: English

Topic: Pediatric Pain Management Techniques

Subfield: Pediatrics, Perinatology and Child Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,590