Effects of Naphtho[2,1- a ]pyrene Exposure on CYP1A1 Expression: An in Vivo and in Vitro Mechanistic Study Exploring the Role of m6A Posttranscriptional Modification
Year: 2024
Type: article
Abstract: BACKGROUND: Currently, many emerging polycyclic aromatic hydrocarbons (PAHs) have been found to be widely present in the environment. However, little has been reported about their toxicity, particularly in relation to CYP1A1. OBJECTIVES: ]pyrene (N21aP) and elucidate the mechanism underlying N21aP-induced expression of CYP1A1. METHODS: mRNA's interaction with IGF2BP3 was confirmed by RNA pull-down, luciferase, and RNA binding protein immunoprecipitation (RIP) assays. RESULTS: mRNA, and finally resulted in an increase in CYP1A1 expression. DISCUSSION: -mediated posttranscriptional modification, jointly contributing to CYP1A1 expression. Given that PAHs are the metabolic substrates of CYP1A1, this study not only helps to understand the significance of environment-genetic interactions for the toxicity of PAHs but also helps to better understand the health risks of the emerging PAHs at environmental exposure levels. https://doi.org/10.1289/EHP14055.
DOI: 10.1289/ehp14055
Authors: Jiemiao Shen, Li Wang, Wen Zhang, Xing Gong, Sheng Li, Xuyan Zou, Chao Chen, Rong Xia, Di Zhang, Shuyu Xu, Jiayi Xu, Shaozhuo Wang, Yinyue Jiang, Hong Sun, Chao Wang, Shou-Lin Wang
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $4,500
OpenAlex ID: W4401513999