Work

Synthesis of 4‐(Phenylamino)quinazoline‐2(1H)‐thiones Using Green Solvents

Year: 2024

Type: article

Abstract: Given the importance of quinazolines and quinazolinethiones in therapeutic and Food and Drug Administration (FDA)-approved molecules, we thought interesting to consider their synthesis in green solvents. We have shown that obtain 4-(arylamino)quinazoline-2-(1H)-thiones and 4-(arylamino)pteridine-2-(1H)-thiones analogues was efficient in green solvents derived from biomass, especially eucalyptol. Although reaction times are somewhat long to achieve good yields, the products were obtained by simple filtration. This considerably limited the loss of atoms due to the use of large quantities of solvents for purification on silica gel columns, and makes our route a sustainable one.

Source: Chemistry - A European Journal

DOI: 10.1002/chem.202402136

Authors: Gatien Messire, Claudie Adolf, Sabine Berteina‐Raboin

Institutions: Université d'Orléans, Centre National de la Recherche Scientifique, Institut de Chimie Organique et Analytique

Language: English

Topic: Quinazolinone synthesis and applications

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Responsible consumption and production

Open Access status: hybrid

Estimated APC paid: $4,640