Work

Photoinduced Copper‐Catalyzed Enantioselective Allylic C(sp3)−H Oxidation of Acyclic 1‐Aryl‐2‐alkyl Alkenes as Limiting Substrates

Year: 2024

Type: article

Abstract: Herein, we disclose a simple copper‐catalyzed method for enantioselective allylic C(sp3)−H oxidation of unsymmetrical acyclic alkenes, specifically 1‐aryl‐2‐alkyl alkenes. The C−H substrates are used in limiting amounts, and the products are obtained with high enantioselectivity, E/Z‐selectivity, and regioselectivity. The method exhibits broad functional group tolerance, and E/Z‐alkene mixtures are suitable C−H substrates. The transformation is enabled by light irradiation, which sustains the enantioselective copper catalysis by photoinduced oxidant homolysis.

Source: Angewandte Chemie

DOI: 10.1002/ange.202413190

Authors: Xuemeng Chen, Heng‐Hui Li, Søren Kramer

Institution: Technical University of Denmark

Language: English

Topic: Oxidative Organic Chemistry Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $5,250

Funders: Novo Nordisk, Danmarks Frie Forskningsfond, Novo Nordisk Fonden