Rosmarinus officinalis essential oil triggers depression followed by CNS excitability in Wistar rats
Year: 2024
Type: article
Abstract: The essential oil of rosemary (Rosmarinus officinalis) (EORO) is widely used in folk medicine and has proven therapeutic effects. Our research evaluated high doses of rosemary essential oil in 54 Wistar rats between 180 and 200 g. The study consisted of three experiments: 1) behavioral monitoring of the animals after administration of 500 mg/kg i.p.; 2) electrocorticographic records after drug administration; 3) anticonvulsant drug reaction, where phenytoin, phenobarbital, and diazepam 10 mg/kg i.p were applied. The results showed that the application of EORO presented two phases. Phase 1 was characterized by the appearance of myorelaxation and a reduction in the power of the electrocorticogram in low-frequency cerebral oscillations. Phase 2 was characterized by increased excitability, with the appearance of convulsions and the increased power of electrocorticographic recordings in cerebral oscillations up to 40 Hz. In this phase, three tracing patterns were observed. Beta oscillations were the most prevalent and were better controlled by diazepam, which demonstrates that the excitatory activity of EORO is related to the reduction of GABAergic activity.
Source: Frontiers in Natural Products
Authors: Daniella Bastos de Araújo, Ysis Nayhara Raiol de Almeida, Maria Klara Otake Hamoy, Luana Vasconcelos de Souza, Priscille Fidelis Pacheco Hartcopff, Rodrigo Gonçalves dos Santos, Lívia Letícia Santos da Silva, Lucas Lima da Rocha, Murilo Farias dos Santos, Yris da Silva Deiga, Rayllan da Cunha Ferreira, Raíssa Vieira de Souza, Gabriela Brito Barbosa, Moisés Hamoy
Institution: Universidade Federal do Pará
Language: English
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,125
OpenAlex ID: W4401517382