Work

Beyond Medicine: Paracetamol as Reagent in Multicomponent Synthesis of 1,3-Benzoxazine

Year: 2024

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide A multicomponent reaction was adapted and successfully applied in the major organic course, which involves synthesizing and characterizing a 1,3-benzoxazine derived from paracetamol extracted from tablets of the worldwide well-known medicine Tylenol. Using paracetamol as a reagent is a motivational strategy in undergraduate laboratories to meet the learning goals of training students in solid–liquid extraction and compound characterization by NMR and FTIR and reaction mechanism discussions in the context of a multicomponent reaction. The multifaceted nature of this experiment encourages students to recognize the potential use of everyday materials as chemical reagents, while providing insights into modern chemistry concepts.

Source: Journal of Chemical Education

DOI: 10.1021/acs.jchemed.4c00143

Authors: Leonardo Antonelli, Rosiene Reis Mattos, Mauricio Moraes Victor, Silvio Cunha

Institution: Universidade Federal da Bahia

Language: English

Topic: Various Chemistry Research Topics

Subfield: Physical and Theoretical Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Fundação de Amparo à Pesquisa do Estado da Bahia