Work

Zn0-Induced Cytotoxicity and Mitochondrial Stress in Microglia: Implications of the Protective Role of Immunoglobulin G In Vitro

Year: 2024

Type: article

Abstract: Background: Zinc (Zn), an essential micronutrient, regulates and maintains neurological functions. However, both Zn deficiency and excess can cause oxidative stress and neurodegenerative diseases. As previously reported, immunoglobulin G (IgG) can modulate oxidative stress in various disorders. Aims: on microglia in vitro. Study Design: In vitro study. Methods: , either alone or with IgG supplementation, was determined with dihydrorhodamine 123 staining. Flow cytometry was employed to ascertain the intracellular protein levels of TRIM21, PINK, PARKIN, MFN2, Beclin-1, and active LC3B. Methods: decreased TRIM21 levels, which is reversed by IgG administration. Conclusion: exposure.

Source: Balkan Medical Journal

DOI: 10.4274/balkanmedj.galenos.2024.2024-4-119

Authors: Katarina Živančević, Başak Aru, Abdullah Demir, Lidija Radenović, Pavle Andjus, Gülderen Yanıkkaya Demirel

Institutions: University of Belgrade, Yeditepe University, Yeditepe University Hospital

Language: English

Topic: Trace Elements in Health

Subfield: Nutrition and Dietetics

Field: Nursing

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: Horizon 2020 Framework Programme