Get started
Work

Human CD29+/CD56+ myogenic progenitors display tenogenic differentiation potential and facilitate tendon regeneration

Year: 2024
Type: preprint
Abstract: Tendon injury occurs at high frequency and is difficult to repair. Identification of human stem cells being able to regenerate tendon will greatly facilitate the development of regenerative medicine for tendon injury. Genetic and functional analyses identify human CD29+/CD56+ myogenic progenitors with tenogenic differentiation potential in vitro and in vivo. Transplantation of human CD29+/CD56+ myogenic progenitors contributes to injured tendon repair and thus improves locomotor function. Interestingly, the tendon differentiation potential in mouse muscle stem cells is minimal and the higher TGFβ signaling level may be the key for the distinct feature of human CD29+/CD56+ myogenic progenitors. The discovery of bi-potential CD29+/CD56+ myogenic progenitors highlights their potential as a novel adult stem cell source for tendon regeneration.
Source: eLife
DOI: 10.7554/elife.98636
Authors: Xiexiang Shao, Xingzuan Lin, Hao Zhou, Minghui Wang, Lili Han, Xin Fu, Sheng Li, Siyuan Zhu, Shenao Zhou, Wenjun Yang, Jianhua Wang, Zhanghua Li, Ping Hu
Institutions: Shanghai Jiao Tong University, Chinese Academy of Sciences, XinHua Hospital, Peking University Third Hospital, Fujian Medical University, Center for Excellence in Molecular Cell Science, State Key Laboratory of Cell Biology, Wuhan University, Wuhan Third Hospital, Guangzhou Laboratory
Language: English
Field: Medicine
Open Access status: gold
Estimated APC paid: $2,500
OpenAlex ID: W4401521379
Cites: 52
Cited by:
Related to: 10