Working memory by distributed neural oscillators in a simple nervous system
Year: 2024
Type: preprint
Abstract: Working memory allows an animal to gather sensory evidence over time, integrate it with evolving internal needs, and make informed decisions about when and how to act. Simple nervous systems enable careful mechanistic dissection of neuronal micro-dynamics underlying putative conserved mechanisms of cognitive function. In this study, we show that the nematode C. elegans makes sensory-guided turns while foraging and can maintain a working memory of sensory activation prior to the execution of a turn. This information is integrated with body posture to localize appetitive stimuli. Using a virtual-reality whole-brain imaging and neural perturbation system, we find that this working memory is implemented by the coupled oscillations of two distributed neural motor command complexes. One complex decouples from motor output after sensory evidence accumulation, exhibits persistent oscillatory dynamics, and initiates turn execution. The second complex serves as a reference timer. We propose that the implementation of working memory via internalization of motor oscillations could represent the evolutionary origin of internal neural processing, i.e. thought, and a foundation of higher cognition.
Institution: University of California, San Francisco
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
Awards: Closed-loop control of neural dynamics and action selection in C elegans, Emergence of Functional Network Dynamics from Single Cell Properties, Olfactory memory acquisition consolidation and recall, The Effects of Stimulation and Sleep on Neural Circuit Connections, Caenorhabditis Genetics Center, Predoctoral Training in Neurobiology
OpenAlex ID: W4401522344