Clinical protocol phase II study of tumor infiltrating lymphocytes in advanced tumors with alterations in the SWI/SNF complex: the TILTS study
Year: 2024
Type: article
Study design: Study Protocol
Abstract: The SWI/SNF complex is a chromatin remodeling complex comprised by several proteins such as SMARCA4 or SMARCB1. Mutations in its components can lead to the development of aggressive rhabdoid tumors such as epithelioid sarcoma, malignant rhabdoid tumor or small cell carcinoma of the ovary hypercalcemic type, among others. These malignancies tend to affect young patients and their prognosis is poor given the lack of effective treatments. Characteristically, these tumors are highly infiltrated by TILs, suggesting that some lymphocytes are recognizing tumor antigens. The use of those TILs as a therapeutic strategy is a promising approach worth exploring. Here, we report the clinical protocol of the TILTS study, a Phase II clinical trial assessing personalized adoptive cell therapy with TILs in patients affected by these tumor types.Clinical Trial Registration: 2023-504632-17-00 (www.clinicaltrialsregister.eu) (ClinicalTrials.gov).
Source: Future Oncology
Authors: Juan Martin-Liberal, Elena Garralda, Jesús García-Donas, Juan José Soto-Castillo, Alberto Mussetti, Carles Codony, Silvia Martin-Lluesma, Susana Muñoz, Vladimir Galvao, Julia Lostes, Marta Rotxes, Cristina Prat-Vidal, Jara Palomero, Ainhoa Muñoz, Rafael Moreno, Xavier García del Muro, Anna Sureda, Ramon Alemany, Alena Gros, Josep Maria Piulats
Language: English
Topic: CAR-T cell therapy research
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4401522490