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Role of urinary nephrin to predict early onset of nephropathy in patients with type 2 diabetes mellitus

Year: 2024

Type: article

Abstract: Nephropathy is most common complication in type 2 diabeticsubjects. Urinary nephrin is a podocyte specific protein, can be serve as a predict early nephropathy and its progression of diabetic nephropathy. A total 90 participants included were sub grouped as 60 cases and 30 healthy controls, a biochemical, clinical and experimental parameters were analyzed for all the study subjects. The data was interpreted by using statistics software SPSS and <0.05 was statistically significant. There were significantly increased levels of FBS, PPBS and glycated haemoglobin in type 2 diabetic cases when compared to controls. The urea, creatinine, uric acid and microalbumin were significantly elevated in type 2 diabetic with microalbuminuria when compared to type 2 diabetic with normoalbuminuria and controls. Additionally the urinary nephrin was significantly elevated in both groups of type 2 diabetics when compared to controls. This study suggests determination of urinary nephrin can be used as an early predictable and prognostic marker for nephropathy in patients with type 2 diabetics.

Source: Panacea Journal of Medical Sciences

DOI: 10.18231/j.pjms.2024.090

Authors: Gadigeppa H Chittaragi, Anand P Ambali, Rajesh Honnutagi, Veluri Ganesh

Institution: Shri BM Patil Medical College

Language: English

Topic: Chronic Kidney Disease and Diabetes

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $48