Work

Human and rat gonadal 3β-hydroxysteroid dehydrogenases are suppressed by dithiocarbamate fungicides via interacting with cysteine residues

Year: 2024

Type: article

Abstract: and steroid-binding sites, with some interactions with cysteine residues. In conclusion, this study provides valuable insights into the structure-activity relationship and mechanistic aspects of dithiocarbamates as inhibitors of human and rat gonadal 3β-HSDs, suggesting that these compounds likely exert their inhibitory effects through binding to cysteine residues.

Source: Ecotoxicology and Environmental Safety

DOI: 10.1016/j.ecoenv.2024.116852

Authors: Xin Zhao, Ting Hao, Jianmin Sang, Miaomiao Xia, Linxi Li, Ren-shan Ge, Congde Chen

Institutions: Wenzhou Medical University, Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University

Language: English

Topic: Effects and risks of endocrine disrupting chemicals

Subfield: Health, Toxicology and Mutagenesis

Field: Environmental Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,990

Funders: Key Program of NSFC-Tongyong Union Foundation, Department of Health of Zhejiang Province, Natural Science Foundation of Shaanxi Provincial Department of Education

Awards: G2268504479, G433440826, G5763584601

OpenAlex ID: W4401528063

FWCI: 1.125

Cites: 26

Cited by: 7

Related to: 10