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Synthesis, in vitro, and in silico study of novel pyridine based 1,3-diphenylurea derivatives as tyrosinase inhibitors

Year: 2024
Type: article
Abstract: value of 3.5 ± 1.2 μM, approximately 5 times more potent than kojic acid. To get further insights into the nature of binding site interactions, molecular docking and molecular dynamics simulation studies were carried out. Moreover, the evaluation of in silico ADME properties showed a highly favorable profile for the synthesized compounds. These findings suggested that the further development of this class of compounds could be useful to get potent drug-like compounds that can target hyperpigmentation-related disorders.
DOI: 10.1016/j.bioorg.2024.107724
Authors: Anam Rubbab Pasha, Majid Khan, Ajmal Khan, Javid Hussain, Mariya al-Rashida, Talha Islam, Zahra Batool, Hamdy Kashtoh, Magda H. Abdellattif, Ahmed Al-Harrasi, Zahid Shafiq, Silvia Schenone
Institutions: Bahauddin Zakariya University, University of Nizwa, Hazara University, Forman Christian College, Yeungnam University, Taif University, University of Genoa
Language: English
Subfield: Cell Biology
Open Access status: hybrid
Estimated APC paid: $4,100
OpenAlex ID: W4401528111
FWCI: 0.946
Cites: 46
Cited by: 5
Related to: 10