Work

NaIO4/NH2OH-mediated Efficient Synthesis of Phosphoroamidates from Anilines and Triethyl Phosphite

Year: 2024

Type: article

Abstract: A simple, efficient, and metal-free method was developed for the synthesis of phosphoroamidates. In essence, a mixture of sodium periodate (NaIO4) and hydroxylamine (NH2OH⸱HCl) was used in stoichiometric amounts to execute the phosphoramidation reaction of aromatic amines and triethyl phosphites at room temperature, in open air. This method offers a practical synthesis route to afford a diverse range of phosphoroamidates via the construction of P − N bonds, with excellent functional group compatibility and good yields under mild conditions.

Source: Sustainability & Circularity NOW

DOI: 10.1055/a-2386-5537

Authors: E. V. Venkat Shivaji Ramarao, Savita Gat, Rana Chatterjee, Jayshree Solanke, Vasudevan Dhayalan, Rambabu Dandela

Institutions: University of Hyderabad, Institute of Chemical Technology, National Institute of Technology, Puducherry

Language: English

Topic: Organophosphorus compounds synthesis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Responsible consumption and production

Open Access status: diamond

Funder: Science and Engineering Research Board