Work

Drug delivery strategies for local immunomodulation in transplantation: Bridging the translational gap

Year: 2024

Type: review

Abstract: Drug delivery strategies for local immunomodulation hold tremendous promise compared to current clinical gold-standard systemic immunosuppression as they could improve the benefit to risk ratio of life-saving or life-enhancing transplants. Such strategies have facilitated prolonged graft survival in animal models at lower drug doses while minimizing off-target effects. Despite the promising outcomes in preclinical animal studies, progression of these strategies to clinical trials has faced challenges. A comprehensive understanding of the translational barriers is a critical first step towards clinical validation of effective immunomodulatory drug delivery protocols proven for safety and tolerability in pre-clinical animal models. This review overviews the current state-of-the-art in local immunomodulatory strategies for transplantation and outlines the key challenges hindering their clinical translation.

Source: Advanced Drug Delivery Reviews

DOI: 10.1016/j.addr.2024.115429

Authors: Afsana Naaz, Heth R. Turnquist, Vijay S. Gorantla, Steven R. Little

Institutions: University of Pittsburgh, McGowan Institute for Regenerative Medicine, Wake Forest University Health Sciences, Wake Forest University

Language: English

Topic: Transplantation: Methods and Outcomes

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $5,150