Gene Electrotransfer via Conductivity‐Clamped Electric Field Focusing Pivots Sensori‐Motor DNA Therapeutics: “A Spoonful of Sugar Helps the Medicine Go Down” (Adv. Sci. 30/2024)
Year: 2024
Type: article
Abstract: Vector-Free Gene Augmentation Therapy In article number 2401392, Jeremy L. Pinyon, Gary D. Housley, and coworkers describe ‘conductivityclamped’ gene electrotransfer (CC-GET) which broadly enables vector-free nucleic acid therapeutics. In preclinical studies, delivery of neurotrophin-encoding plasmid DNA to the deafened cochlea drove auditory nerve regeneration. In the brain, CC-GET enabled focal expression of photo-activated ion channels that modulated neural excitability relevant to treatment of Parkinson's Disease.
Source: Advanced Science
Authors: Jeremy L. Pinyon, Georg von Jonquieres, Edward N. Crawford, Amr Al Abed, John M. Power, Matthias Klugmann, Cherylea J. Browne, David M. Housley, Andrew K. Wise, James B. Fallon, Robert K. Shepherd, John Y. Lin, Catherine McMahon, David McAlpine, Catherine S. Birman, Waikong Lai, Ya Lang Enke, Paul M. Carter, James F. Patrick, Robert D. Gay, Corinne Marie, Daniel Scherman, Nigel H. Lovell, Gary D. Housley
Language: English
Subfield: Biotechnology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $6,120
OpenAlex ID: W4401529515