The Hippocampus Represents Information about Movements in Their Temporal Position in a Learned Motor Sequence
Year: 2024
Type: article
Abstract: Our repertoire of motor skills is filled with sequential movements that need to be performed in a specific order. Here, we used functional magnetic resonance imaging to investigate whether the human hippocampus, a region known to support temporal order in non-motor memory, represents information about the order of sequential motor actions in human participants (both sexes). We also examined such representations in other regions of the motor network (i.e., the premotor cortex, supplementary motor area, anterior superior parietal lobule, and striatum) already known for their critical role in motor sequence learning. Results showed that the hippocampus represents information about movements in their learned temporal position in the sequence, but not about movements or temporal positions in random movement patterns. Other regions of the motor network coded for movements in their learned temporal position, as well as movements and positions in random movement patterns. Importantly, movement coding contributed to sequence learning patterns in primary, supplementary, and premotor cortices but not in striatal and parietal regions. Our findings deepen our understanding of how striatal and cortical regions contribute to motor sequence learning and point to the capacity of the hippocampus to represent movements in their temporal context, an ability possibly explaining its contribution to motor learning.
Source: Journal of Neuroscience
Institutions: Columbia University, KU Leuven, University of Utah
Language: English
Topic: Memory and Neural Mechanisms
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
Awards: Optimizing Memory in Humans: Neurophysiological Modulation of Motor Memory Acquisition and Consolidation, Speeding Up the Learning Process: A Multimodal Neuroimaging Investigation into the Acceleration of Motor Memory Consolidation, Modulating memory consolidation with non-invasive brain stimulation: a multimodal neuroimaging investigation, G4254685185, Influence of Stress on the Neural Correlates of Motor Memory Acquisition and Sleep-Related Consolidation, Optimizing Motor Memory in Healthy Older Adults via Feedback-Controlled Non-Invasive Brain Stimulation during Sleep: A Neuroimaging Investigation, Expert deep learning in the human brain: a cognetive computational neuroscience perspective
OpenAlex ID: W4401536693