M1 macrophage-membrane-cloaked paclitaxel/β-elemene nanoparticles targeting cervical cancer for enhanced therapy
Year: 2024
Type: article
Abstract: cervical cancer models, we demonstrated that M1@PLGA/PTX/β-ELE effectively suppressed tumor progression and polarization of tumor-associated macrophages. Furthermore, H&E staining confirmed the high therapeutic biosafety of M1@PLGA/PTX/β-ELE as there was no significant damage observed in major organs throughout the entire therapeutic process. Overall, this study presents a targeted biomimetic nanoplatform and combinatorial strategy that synergistically enhances chemosensitivity in malignant tumors.
Authors: Yi Wang, Jiakun Wang, Chengbo Huang, Yang Ding, Leyao Lv, Yuhao Zhu, Nuo Chen, Yingyi Zhao, Qing Yao, Shengjie Zhou, Mei Chen, Qibing Zhu, Lifeng Li, Fengyun Chen
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,700
Funder: Wenzhou Medical University
OpenAlex ID: W4401537135