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Synthesis and photo-induced anticancer activity of new 2-phenylethenyl-1H-benzo[e]indole dyes

Year: 2024
Type: article
Abstract: Herein, a series of new 1,1,2-trimethyl-1H-benzo[e]indole dyes was prepared via Knoevenagel condensation reaction between 1,1,2-trimethyl-1H-benzo[e]indole and benzaldehydes, and characterized using various spectroscopic methods. The obtained compounds showed cytotoxic properties in G361 melanoma cell line upon irradiation with 414 nm blue light at submicromolar doses. The mechanism of action of the most potent compound 15 was further investigated. The treatment induced substantial generation of reactive oxygen species, leading to DNA damage followed by cell death depending on the concentration of the photosensitizer compound and the irradiation intensity.
DOI: 10.1016/j.ejmech.2024.116777
Authors: Gabrielė Varvuolytė, Eva Řezníčková, Sonata Krikštolė, Rasa Tamulienė, Aurimas Bieliauskas, Lukáš Malina, Veronika Vojáčková, Zdenko Duben, Hana Kolářová, Neringa Kleizienė, Eglė Arbačiauskienė, Asta Žukauskaitė, Vladimír Kryštof, Algirdas Šačkus
Language: English
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $4,850
Funders: European Commission, European Geosciences Union, Academy of Finland, Lietuvos Mokslo Taryba, Univerzita Palackého v Olomouci, Jiangsu University of Technology, Kauno Technologijos Universitetas
OpenAlex ID: W4401538311
FWCI: 1.52
Cites: 56
Cited by: 6
Related to: 10