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High serum levels of reactive nitrogen species and low total antioxidant capacity in patients with resistant hypertension compared to those in age- gender matched healthy controls, controlled hypertension and follow up with propranolol treatment in the extended APPROPRIATE trial

Year: 2024

Type: article

Abstract: To perform a comparative analysis of the extended APPROPRIATE trial of measures of reactive nitrogen species and antioxidant capacity in patients having resistant hypertension with controlled hypertension and healthy controls. Mean serum NO 2 - and NOx levels were significantly lower and mean AOC was significantly higher in patients with controlled hypertension ( n = 38) and healthy controls ( n = 38) compared to resistant hypertension (RHTN) patients ( n = 40) at the pre-intervention stage ( p < 0.001). The serum NO 2 -, NOx and AOC levels of both controlled hypertension and healthy controls were comparable to those of the RHTN patients following treatment with propranolol ( n = 18). Considering all samples ( n = 114) we noted that there were significant weak and moderate positive correlations between NO 2 − levels with systolic blood pressure (SBP) and diastolic blood pressure (DBP) ( r = 0.396, p < 0.001 and r = 0.292, p = 0.004) as well as total NOx levels with SBP and DBP ( r = 0.636 and r = 0.480 respectively, p < 0.001). Conversely, there was a significant negative correlation between AOC levels with SBP and DBP ( r = -0.846 and r = -0.626 respectively, p < 0.001).

Source: BMC Research Notes

DOI: 10.1186/s13104-024-06884-8