Nanoengineered mitochondria enable ocular mitochondrial disease therapy via the replacement of dysfunctional mitochondria
Year: 2024
Type: article
Abstract: an enhanced PARKIN-mediated mitophagy process. In a mouse model induced with a complex I inhibitor (rotenone, Rot), mNP-Mito enhanced the presence of healthy mitochondria and exhibited a sharp increase in complex I activity (76.5%) compared to the group exposed to Rot damage (29.5%), which greatly promoted the restoration of ATP generation and mitigation of ocular mitochondrial disease-related phenotypes. This study highlights the significance of nanoengineered mitochondria as a promising and feasible tool for the replacement of dysfunctional mitochondria and the repair of mitochondrial function in mitochondrial disease therapies.
Source: Acta Pharmaceutica Sinica B
Authors: Yi Wang, Nahui Liu, Lifan Hu, Jingsong Yang, Mengmeng Han, Tianjiao Zhou, Lei Xing, Hulin Jiang
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,600
Funders: Tianjin Postdoctoral Science Foundation, National Natural Science Foundation of China, China Pharmaceutical University, China Postdoctoral Science Foundation, Government of Jiangsu Province, Natural Science Foundation of Jiangsu Province, National Aerospace Science Foundation of China, State Key Laboratory of Natural Medicines, Support Program for Longyuan Youth and Fundamental Research Funds for the Universities of Gansu Province, Natural Science Foundation for Young Scientists of Shanxi Province, Program for New Century Excellent Talents in University, Fundamental Research Funds for the Central Universities, State Key Laboratory Opening Project of Northeastern University
OpenAlex ID: W4401539251