Work

Auto-expansion of in vivo HDAd-transduced hematopoietic stem cells by constitutive expression of tHMGA2

Year: 2024

Type: article

Abstract: transduced HSCs resulting in transgene-marking rates that, theoretically, are curative for hemoglobinopathies.

Source: Molecular Therapy — Methods & Clinical Development

DOI: 10.1016/j.omtm.2024.101319

Authors: Hongjie Wang, Aphrodite Georgakopoulou, Evangelos Nizamis, Ka Wai Mok, Raïssa Eluère, Robert A. Policastro, Paul N. Valdmanis, André Lieber

Institution: University of Washington

Language: English

Topic: Virus-based gene therapy research

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,900

Funders: Bill and Melinda Gates Foundation, National Institutes of Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases

Awards: University of Washington - to explore new, low cost capabilities for the in vivo delivery of durable suppression therapies of HIV in developing countries, G1534023477, G4840118924, G7796778158

OpenAlex ID: W4401539364

FWCI: 0.981

Cites: 78

Cited by: 4

Related to: 10