Chlorpyrifos induces cytotoxicity via oxidative stress and mitochondrial dysfunction in HepG2 cells
Year: 2024
Type: article
Abstract: (by 20%). CPF also upregulated Nrf2 protein expression, indicating the role of the latter in modulating the cellular response to oxidative insults. Overall, our findings suggest that CPF caused hepatotoxicity through oxidative stress and mitochondrial dysfunction. Given the re-emerging use of CPF, this study emphasizes the need for comprehensive analysis to elucidate its toxicity on non-target organs and associated mechanisms.
Source: Food and Chemical Toxicology
Authors: C. Montanarí, F. Franco-Campos, M. Taroncher, Y. Rodríguez-Carrasco, V. Zingales, M.J. Ruiz
Institution: Universitat de València
Language: English
Subfield: Plant Science
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,520
Funders: United States Agency for International Development, Ministerio de Ciencia, Innovación y Universidades, Generalitat Valenciana, Ministerio de Ciencia e Innovación, Karl und Veronica Carstens-Stiftung, Agencia Estatal de Investigación, Spanish National Plan for Scientific and Technical Research and Innovation
OpenAlex ID: W4401539511