Synthesis of N-Alkyl-Substituted Aziridines and Oxazolidine Based on Levoglucosenone Derivatives
Year: 2024
Type: article
Abstract: Diastereomeric oxazolidines were obtained in quantitative yield by boiling levoglucosenone (cyrene) derivative in benzene with ethanolamine. Sterocontrolled synthesis of N-propyl, -butyl, -lauryl aziridines annulated with a pyran ring based on the α-bromoderivative of levoglucosenone and the corresponding amines was carried out under ultrasonic irradiation of the mixture in the presence of an accessible base K₂CO₃ and catalytic amounts 18-crown-6-ether in toluene. The obtained nitrogen-containing heterocycles are promising in terms of structure–activity studies in the synthesized series of compounds.
Source: Журнал Общей Химии
Institutions: Russian Academy of Sciences, Ufa Institute of Chemistry
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W4401539965