Work

Three-Component Synthesis of 5-Aryl(hetaryl)-4-aroyl-1-isobutyl-3-hydroxy-3-pyrroline-2-ones

Year: 2024

Type: article

Abstract: A series of new 5-aryl(hetaryl)-4-aroyl-1-isobutyl-3-hydroxy-3-pyrrolin-2-ones were synthesized by reacting methyl esters of aroylpyruvic acids with aromatic (heterocyclic) aldehydes and isobutylamine in dioxane. Antimicrobial activity of the obtained compounds was studied in vitro against Staphylococcus aureus, Escherichia coli and Candida albicans strains.

Source: Журнал Общей Химии

DOI: 10.31857/s0044460x24030039

Authors: V. L. Gein, D. G. Dianova, O. O. Senokosova, N. V. Nosova, E. A. Buldakova, I. G. Mokrushin

Institution: Perm State Pharmaceutical Academy

Language: English

Topic: Synthesis and Characterization of Pyrroles

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

OpenAlex ID: W4401540069

FWCI: 0.419

Cites: 7

Cited by: 3

Related to: 10