Work

Biosynthesis and in vivo wound healing abilities of Dactyloctenium aegyptium-mediated silver nanoparticles used as hydrogel dressing

Year: 2024

Type: article

Abstract: Wounds offer a suitable medium for the growth of pathogenic microorganisms as well as their entry into the body to cause harm, which necessitates the existence and development of effective wound healing treatments. Nanotechnology provides an opportunity for the development of economical and effective novel wound-healing systems. In the current study, a green route has been employed for silver nanoparticles (AgNPs) production, using Dactyloctenium aegyptium (D. aegyptium) aqueous extract as both a capping and reducing agent. Synthesized AgNPs-DA were characterized through UV-Vis spectroscopy, FT-IR, SEM, and XRD, and in vitro antibacterial activity against gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa) bacterial strains. An optimized formulation was incorporated into PVA, Na-Alginate, and gelatin-based hydrogel dressings for the investigation of in vivo wound healing capability in mice. The color change of the reaction mixture and surface plasmon resonance around 400 nm confirmed the formation of AgNPs. FT-IR analysis revealed the involvement of phytochemicals present in the aqueous plant extract in the capping and stabilization of AgNPs. The nanoparticles were crystalline in nature with an average crystallite size of 28.03 nm and exhibited antibacterial activity against tested strains. Further, AgNPs-DA-loaded hydrogels showed accelerated wound healing in rats in comparison to untreated rats and rats treated with a commercial product. Thus, the developed hydrogel dressing has potential for clinical application in wound healing and the treatment of infection.

Source: Process Biochemistry

DOI: 10.1016/j.procbio.2024.08.011

Authors: Maryam Zain, Sana Nayab, Zermina Rashid, Ambreen Aleem, Hina Raza, Mohamed Deifallah Yousif

Institutions: The Women University Multan, UCL School of Pharmacy, University College London, Bahauddin Zakariya University

Language: English

Topic: Nanoparticles: synthesis and applications

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,050