Work

Laterality, heterotaxy, and isolated congenital heart defects

Year: 2024

Type: article

Abstract: To date, the role of NODAL in normal and abnormal L-R asymmetry has been well established. In a recent paper, mutations of this gene have been reported in heterotaxy but also in transposition with D- or L-ventricular loop. The effects of NODAL and other laterality genes can be recognized separately in all three cardiac segments: for topology and septation of the atria, for ventricular looping, and for spiralization and alignment of the great arteries.

Source: Genome Medicine

DOI: 10.1186/s13073-024-01375-8

Authors: Carolina Putotto, Flaminia Pugnaloni, Marta Unolt, Giulio Calcagni, Paolo Versacci, Bruno Marino

Institutions: Sapienza University of Rome, Bambino Gesù Children's Hospital, Istituti di Ricovero e Cura a Carattere Scientifico

Language: English

Topic: Congenital heart defects research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $5,090

OpenAlex ID: W4401542727

FWCI: 0.824

Cites: 10

Cited by: 7

Related to: 10