Microfluidic assay devices integrated with Au nanorods for rapid and sensitive detection of cardiac troponin I
Year: 2024
Type: conference-paper
Abstract: We present a microfluidic assay device integrated with Au nanorods for rapid and sensitive detection of Cardiac troponin I (cTnI), the current gold standard biomarker for diagnosing acute myocardial infarction. The Au nanorods, fabricated using oblique angle deposition (OAD), significantly enhance fluorescent signals, thereby eliminating the need for high-resolution lithography technologies. Leveraging this device, rapid and sensitive detection of cTnI is realized with a limit of detection (LOD) of 6.9 pg mL−1 within 6 minutes, referring to a sensitivity enhancement of 4000-fold compared to glass substrates. Given its simple fabrication method, ease of operation, and highly sensitive immunoassay performance, this device holds great potential for clinical and point-of-care testing (POCT) applications.
Authors: Xuefeng Xu, Guangyang Li, Lingyue Xue, MingZhu Xu, Sixing Hu, Anli Xiang, Xi Yang, Jiaqi Lu, Zhen Cao
Institution: Zhejiang University
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4401544812