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Figure 1 from BRCA Status Dictates Wnt Responsiveness in Epithelial Ovarian Cancer

Year: 2024

Type: other

Abstract: Transcriptomic differences between patients with BRCA1mt, BRCA2mt, and HRwt ovarian cancer. RNA-seq was performed on patients with HRwt (n = 375), BRCA1mt (n = 16), and BRCA2mt (n = 15) ovarian cancer. A, Volcano plots showing the distribution of DEGs (P = 0.05; FC > 1.5) in the compared groups as indicated. B, Venn diagram of DEGs in each of the groups compared showing 163 genes unique to BRCA2mt tumors. C, Venn diagram of differentially regulated pathways in each of the groups compared showing six pathways unique to BRCA2mt tumors compared with BRCA1mt and HRwt; these six pathways are shown in D.

DOI: 10.1158/2767-9764.26553505.v1

Authors: Hussein Chehade, Radhika Gogoi, Nicholas K. Adzibolosu, Sandra Galoforo, Rouba-Ali Fehmi, Mira Kheil, Alexandra Fox, Seongho Kim, Ramandeep Rattan, Zhanjun Hou, Robert T. Morris, Larry H. Matherly, Gil Mor, Ayesha B. Alvero

Language: English

Topic: BRCA gene mutations in cancer

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4401552469

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