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Figure 2 from BRCA Status Dictates Wnt Responsiveness in Epithelial Ovarian Cancer

Year: 2024

Type: other

Abstract: Wnt signaling is predicted to be inhibited in BRCA2mt ovarian tumors. A, DEGs comparing BRCA2mt vs. BRCA1mt and (B) BRCA2mt vs. HRwt reported as logFC; red bars represent upregulated, and blue bars represent downregulated; note that several Wnt inhibitors are upregulated in BRCA2mt tumors (red asterisk). C, Perturbation analysis of the Wnt signaling pathway comparing BRCA2mt and BRCA1mt tumors; red genes are predicted to be upregulated, and blue genes are predicted to be downregulated; the dashed circle shows β-catenin is predicted to be downregulated. Red arrows indicate upregulation of several Wnt signaling inhibitors at the level of the receptor.

DOI: 10.1158/2767-9764.26553499

Authors: Hussein Chehade, Radhika Gogoi, Nicholas K. Adzibolosu, Sandra Galoforo, Rouba-Ali Fehmi, Mira Kheil, Alexandra Fox, Seongho Kim, Ramandeep Rattan, Zhanjun Hou, Robert T. Morris, Larry H. Matherly, Gil Mor, Ayesha B. Alvero

Language: English

Topic: Wnt/β-catenin signaling in development and cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4401552797

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