Autism, youth suicide, and psychedelics: A review of the 21st century evidence
Year: 2024
Type: article
Abstract: The concurrent rise in the prevalence of autism and youth suicide has drawn public health and professional attention. The renaissance of psychedelics in psychiatry occurred in the early 21st century and may suggest a hope for the therapeutic effect of psychedelics in autism and suicide. The psychedelics' molecular entities are the compounds that modulate the serotoninergic and glutamatergic systems, which play a crucial role in the pathomechanisms underlying autism and suicide. This systematic review comprehensively discussed the prevalence trends of autism and youth suicide globally and in Taiwan and discussed an association between autism and suicidality based on the 21st century clinical and preclinical literature. Furthermore, this review proposed a possible neurobiological connection between autism, suicide, and psychedelics. Finally, this review discussed the potential therapeutic applications of psychedelics in autism and youth suicide.
Language: English
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: hybrid
Funders: Academia Sinica, Ministry of Science and Technology, Taiwan, University System of Taiwan, National Taiwan University, Yen Tjing Ling Medical Foundation, Tri-Service General Hospital, Taipei Veterans General Hospital, Kaohsiung Veterans General Hospital, National Science and Technology Council
Awards: G1259558558, G1292966817, G1454187482, G1743868987, G2191060952, G2521928599, G2530793813, G262263919, G265016787, G2826141355, G2889430041, G3048717457, G3108854269, G3326762266, Low-Dose Ketamine Infusion among Adolescents with Treatment-Resistant Depression: a Randomized, Double-Blind Placebo-Control Study, G3758813513, G40078815, G4427410683, G449856906, G4567487053, G4942875564, G5012695417, G5072617215, Modulation of the Antidepressant and Antisuicidal Efficacy of Low-Dose Ketamine Infusion via the Mtorc1 Modulator, Rapamycin: a Double-Blind, Randomized, Placebo Controlled Trial Combined with the Neuropsychological and Functional Connectivity Mri Study., Anti-Inflammation Treatment of Mood Disorders and Deep Learning Prediction Model, G5285952827, G5343291647, G5553168031, Emotional Dysregulation as a Transdiagnostic Clinical Domain between Adolescent Adhd and Major Affective Disorders: a Prospective Neuroimaging and Neuropsychological Study, Low-Dose Ketamine Infusion among Adolescents with Treatment-Resistant Depression: a Randomized, Double-Blind Placebo-Control Study., G8821328323
OpenAlex ID: W4401554246