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Figure 5 from BRCA Status Dictates Wnt Responsiveness in Epithelial Ovarian Cancer

Year: 2024

Type: other

Abstract: The noncanonical Wnt pathway is activated upon loss of BRCA1. A, Model of the noncanonical Wnt signaling pathway. B, ID8 mouse ovarian cancer cells were treated with 100 ng/mL Wnt3A followed by immunofluorescence for F-actin (green). DAPI staining is shown in blue. Red arrows point to F-actin filaments. Images show both green and DAPI channels. C, Biological processes related to filament and microtubule polymerization are differentially regulated in BRCA1mt vs. BRCA2mt and HRwt ovarian tumors. DAPI, 4′,6′-diamidino-2-phenylindole.

DOI: 10.1158/2767-9764.26553484.v1

Authors: Hussein Chehade, Radhika Gogoi, Nicholas K. Adzibolosu, Sandra Galoforo, Rouba-Ali Fehmi, Mira Kheil, Alexandra Fox, Seongho Kim, Ramandeep Rattan, Zhanjun Hou, Robert T. Morris, Larry H. Matherly, Gil Mor, Ayesha B. Alvero

Language: English

Topic: Wnt/β-catenin signaling in development and cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4401554592

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