Figure 5 from Acetalax (Oxyphenisatin Acetate, NSC 59687) and Bisacodyl Cause Oncosis in Triple-Negative Breast Cancer Cell Lines by Poisoning the Ion Exchange Membrane Protein TRPM4
Year: 2024
Type: other
Abstract: TRPM4 targeting and proteasomal degradation of TRPM4 by Acetalax and bisacodyl. A, Western blot of TRPM4 protein levels in MDA-MB468 following Acetalax treatment. B, Western blot of TRPM4 protein levels in MDA-MB468 following Acetalax and MG132 proteasome inhibitor treatment. C, Western blot of TRPM4 protein levels in MDA-MB468 following bisacodyl treatment. D, Western blot of TRPM4 protein levels in MDA-MB468 following bisacodyl and MG132 proteasome inhibitor treatment. The presence or absence of Acetalax or bisacodyl and MG132 is indicated in each experiment by + and/or − above each column. Cells were treated with Acetalax for 4 hours at 10 μmol/L and bisacodyl at 30 μmol/L. Cells were treated with MG132 for 4 hours at 20 μmol/L.
Language: English
Topic: Ion Channels and Receptors
Subfield: Sensory Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4401585096